Phenoxybenzamine Hydrochloride
PrescriptionHandelsnamen: Phenoxybenzamine hydrochloride
About This Medication
DESCRIPTION Each phenoxybenzamine hydrochloride capsule, USP with red cap and body, is imprinted with “Amneal” on cap and “1502” on body, and contains 10 mg of phenoxybenzamine hydrochloride, USP. Inactive ingredients consist of colloidal silicon dioxide, D&C red 33, FD & C red 3, gelatin, iron oxide yellow, lactose monohydrate and sodium lauryl sulfate. The capsule is imprinted with white pharmaceutical ink which contains butyl alcohol, dehydrated alcohol, isopropyl alcohol, potassium hydroxide, propylene glycol, shellac, strong ammonia solution and titanium dioxide. Phenoxybenzamine hydrochloride is chemically known as N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl) benzylamine hydrochloride. Its molecular formula is C 18 H 22 ClNO·HCl. The chemical structure is: Phenoxybenzamine hydrochloride, USP is a white to almost white crystalline powder with a molecular weight of 340.29 g/mol, which melts between 136° and 141°C. It is freely soluble in ethanol (96%) and insoluble in diethyl ether. FDA approved organic impurity specification differs from the USP. 1
Wirkstoffe
| Wirkstoff | Stärke |
|---|---|
| Phenoxybenzamine Hydrochloride | - |
Indikationen und Anwendung
Dosierung und Verabreichung
Side Effects Overview
Warnhinweise und Vorsichtsmaßnahmen
WARNING Phenoxybenzamine hydrochloride-induced alpha -adrenergic blockade leaves beta -adrenergic receptors unopposed. Compounds that stimulate both types of receptors may, therefore, produce an exaggerated hypotensive response and tachycardia.
Kontraindikationen
CONTRAINDICATIONS Conditions where a fall in blood pressure may be undesirable; hypersensitivity to the phenoxybenzamine hydrochloride capsules, or any of its components.
Frequently Asked Questions
INDICATION AND USAGE Phenoxybenzamine hydrochloride capsules are indicated in the treatment of pheochromocytoma, to control episodes of hypertension and sweating. If tachycardia is excessive, it may be necessary to use a beta -blocking agent concomitantly.
DOSAGE AND ADMINISTRATION The dosage should be adjusted to fit the needs of each patient. Small initial doses should be slowly increased until the desired effect is obtained or the side effects from blockade become troublesome. After each increase, the patient should be observed on that level before instituting another increase . The dosage should be carried to a point where symptomatic relief and/or objective improvement are obtained, but not so high that the side effects from blockade become troublesome. …
WARNING Phenoxybenzamine hydrochloride-induced alpha -adrenergic blockade leaves beta -adrenergic receptors unopposed. Compounds that stimulate both types of receptors may, therefore, produce an exaggerated hypotensive response and tachycardia.
CONTRAINDICATIONS Conditions where a fall in blood pressure may be undesirable; hypersensitivity to the phenoxybenzamine hydrochloride capsules, or any of its components.
Phenoxybenzamine Hydrochloride is a prescription medication. You will need a valid prescription from a licensed healthcare provider.
Similar Capsule Products
Browse all Capsule products →References & Data Sources
- • DailyMed — Phenoxybenzamine Hydrochloride drug label (National Library of Medicine)
- • openFDA — Phenoxybenzamine Hydrochloride label data (U.S. Food & Drug Administration)
- • RxNorm — RXCUI 861402 (NLM Normalized Drug Names)
- • NDC Directory — Phenoxybenzamine Hydrochloride (FDA National Drug Code)
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Datenquellen: DailyMed (NLM), openFDA, MFDS