Bioavailability

Definición

The fraction of an administered drug dose that reaches systemic circulation in unchanged form. Intravenous drugs have 100% bioavailability by definition, while oral drugs are typically lower due to incomplete absorption and first-pass metabolism in the liver.

Términos Relacionados

Mencionado en Guías

• Understanding Drug Expiration Dates
  Drug expiration dates are set by manufacturers based on stability testing, but their practical meaning is more nuanced than most …
• Food-Drug Interactions Guide
  How everyday foods — from grapefruit to leafy greens and dairy — can change the way your medications work, and …
• How Your Body Absorbs Medication
  From the moment you swallow a pill to the point it reaches your bloodstream, your body runs a complex absorption …
• Timing Your Medications for Best Effect
  When you take a medication can be as important as how much you take. Timing affects absorption, peak blood levels, …
• Complete Guide to Thyroid Medications
  An informative guide to medications for hypothyroidism and hyperthyroidism — covering levothyroxine, antithyroid drugs, and the importance of therapeutic monitoring …
• Generic Drugs: Safety, Savings, and Myths
  Generics account for over 90% of US prescriptions yet cost a fraction of brand-name drugs. This guide explains FDA bioequivalence …
• The Microbiome and Drug Metabolism
  Trillions of bacteria in your gut can transform drugs before they even reach your bloodstream. Learn how the gut microbiome …