Volume of Distribution
VdDefinición
A theoretical volume that relates the total amount of drug in the body to its plasma concentration. A large Vd indicates the drug distributes extensively into tissues, while a small Vd suggests the drug remains primarily in the blood.
Ejemplo
Chloroquine has a very high Vd (~200 L) because it concentrates in tissues, while warfarin has a low Vd (~8 L) because it stays mostly in the blood bound to albumin.
Términos Relacionados
Mencionado en Guías
-
Pediatric Dosing PrinciplesWhy children are not simply small adults when it comes to medications — how age and weight affect dosing, why …
-
Obesity and Medication DosingHow obesity changes drug distribution and metabolism, why standard doses may be inadequate or excessive in people with obesity, and …