Hepatic Dosing Adjustment
Definisi
Modification of drug dose for patients with liver disease, as the liver is the primary site of drug metabolism. Unlike renal adjustment, hepatic adjustment is less formulaic because liver function tests (ALT, AST) don't directly correlate with metabolic capacity. The Child-Pugh score is used to guide dosing.
Contoh
For a patient with Child-Pugh Class C cirrhosis, the starting dose of most hepatically metabolized drugs should be reduced by 50% or more.
Istilah Terkait
Disebutkan dalam Panduan
-
Medications for Older AdultsAging changes how the body processes medications, increases the risk of drug interactions, and creates unique challenges in managing multiple …
-
Drug-Induced Liver Injury (DILI)Drug-induced liver injury (DILI) is one of the most serious medication side effects and a leading cause of acute liver …
-
Liver Disease and Medication DosingThe liver metabolizes most medications. When liver function is impaired, drugs can build up to dangerous levels or fail to …
-
Geriatric PharmacologyHow aging changes the way the body handles medications, why older adults are more vulnerable to side effects, and practical …
-
Medications and Liver DiseaseHow liver disease affects drug metabolism and first-pass elimination, why hepatic dose adjustments are less predictable than renal adjustments, and …