Cytochrome P450

Définition

A superfamily of liver enzymes responsible for metabolizing approximately 75% of all drugs. Key isoforms include CYP3A4 (metabolizes ~50% of drugs), CYP2D6, CYP2C9, and CYP1A2. Drugs that inhibit or induce these enzymes can significantly alter the metabolism of other medications.

Termes Associés

Mentionné dans les Guides

• The CYP450 System Explained
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• Alcohol and Medications
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• Herbal Supplements and Drug Interactions
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• Blood Thinner Interactions
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• Antidepressant Interactions
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• Antibiotics and Other Drug Interactions
  A practical guide to the most important antibiotic-drug interactions — including effects on warfarin, oral contraceptives, antacids, and the risk …
• Medications and Liver Disease
  How liver disease affects drug metabolism and first-pass elimination, why hepatic dose adjustments are less predictable than renal adjustments, and …
• Pharmacogenomics: Your Genes and Your Drugs
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• The Microbiome and Drug Metabolism
  Trillions of bacteria in your gut can transform drugs before they even reach your bloodstream. Learn how the gut microbiome …