Enzyme Induction
Definisi
The process by which a drug increases the production of metabolizing enzymes (particularly CYP450), leading to faster breakdown of itself or other drugs. This can reduce the effectiveness of co-administered medications. Induction typically takes days to weeks to develop fully.
Contoh
Rifampin is a potent CYP3A4 inducer that can reduce the effectiveness of oral contraceptives, potentially leading to unintended pregnancy.
Istilah Terkait
Disebutkan dalam Panduan
-
The CYP450 System ExplainedAn accessible explanation of the cytochrome P450 enzyme system — the liver's main drug-processing machinery and the source of most …
-
Herbal Supplements and Drug InteractionsA science-based guide to how popular herbal supplements — St. John's Wort, ginkgo, echinacea, and others — interact with prescription …