Therapeutic Drug Monitoring

TDM

Definisi

The measurement of drug concentrations in blood at specific times to optimize individual dosing. TDM is essential for drugs with narrow therapeutic indices, significant pharmacokinetic variability, or serious toxicity. Common drugs requiring TDM include lithium, vancomycin, aminoglycosides, and immunosuppressants.

Contoh

Vancomycin trough levels are measured before the next dose to ensure they remain within the therapeutic range (15-20 mcg/mL for serious infections).

Istilah Terkait

Clearance CL Steady State Css Therapeutic Index TI

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