Noxivent 102
PrescriptionТорговые наименования: Noxivent 102
About This Medication
11. DESCRIPTION Noxivent™ (nitric oxide gas) is a drug administered by inhalation. Nitric oxide, the active substance in Noxivent™, is a pulmonary vasodilator. Noxivent™ is a gaseous blend of nitric oxide and nitrogen (0.08% and 99.92%, respectively for 800 ppm; 0.01% and 99.99%, respectively for 100 ppm). Noxivent™ is supplied in aluminum cylinders as a compressed gas under high pressure (2000 pounds per square inch gauge [psig]). The structural formula of nitric oxide (NO) is shown below: formula
Действующие Вещества
| Компонент | Дозировка |
|---|---|
| Nitric Oxide | - |
Показания и Применение
Дозировка и Способ Применения
Side Effects Overview
Предупреждения и Меры Предосторожности
WARNINGS AND PRECAUTIONS Rebound: Abrupt discontinuation of Noxivent™ may lead to worsening oxygenation and increasing pulmonary artery pressure ( 5.1 ). Methemoglobinemia: Methemoglobin increases with the dose of nitric oxide; following discontinuation or reduction of nitric oxide, methemoglobin levels return to baseline over a period of hours ( 5.2 ). Elevated NO 2 Levels: Monitor NO 2 levels ( 5.3 ). Heart Failure: In patients with pre-existing left ventricular dysfunction, Noxivent™ may increase pulmonary capillary wedge pressure leading to pulmonary edema ( 5.4 ).
Противопоказания
CONTRAINDICATIONS Neonates dependent on right-to-left shunting of blood ( 4 ).
Frequently Asked Questions
INDICATIONS AND USAGE Noxivent™ is a vasodilator indicated to improve oxygenation and reduce the need for extracorporeal membrane oxygenation in term and near-term (>34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in conjunction with ventilatory support and other appropriate agents.
DOSAGE AND ADMINISTRATION The recommended dose is 20 ppm, maintained for up to 14 days or until the underlying oxygen desaturation has resolved ( 2.1 ). Doses greater than 20 ppm are not recommended ( 2.1 , 5.2 ) Administration: • Avoid abrupt discontinuation ( 2.2 , 5.1 ).
WARNINGS AND PRECAUTIONS Rebound: Abrupt discontinuation of Noxivent™ may lead to worsening oxygenation and increasing pulmonary artery pressure ( 5.1 ). Methemoglobinemia: Methemoglobin increases with the dose of nitric oxide; following discontinuation or reduction of nitric oxide, methemoglobin levels return to baseline over a period of hours ( 5.2 ). Elevated NO 2 Levels: Monitor NO 2 levels ( 5.3 ). Heart Failure: In patients with pre-existing left ventricular dysfunction, Noxivent™ may increase pulmonary capillary wedge pressure leading to pulmonary …
CONTRAINDICATIONS Neonates dependent on right-to-left shunting of blood ( 4 ).
Noxivent 102 is a prescription medication. You will need a valid prescription from a licensed healthcare provider.
Similar Inhaler Products
Browse all Inhaler products →References & Data Sources
- • DailyMed — Noxivent 102 drug label (National Library of Medicine)
- • openFDA — Noxivent 102 label data (U.S. Food & Drug Administration)
- • RxNorm — RXCUI 582608 (NLM Normalized Drug Names)
- • NDC Directory — Noxivent 102 (FDA National Drug Code)
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Источники данных: DailyMed (NLM), openFDA, MFDS