First-Pass Effect
التعريف
The phenomenon where an orally administered drug is significantly metabolized by the liver before reaching systemic circulation. This reduces the amount of active drug available to the body and is a major reason why oral doses are often higher than intravenous doses of the same drug.
مثال
Nitroglycerin undergoes extensive first-pass metabolism, which is why it's given sublingually (under the tongue) rather than swallowed.
المصطلحات ذات الصلة
مذكور في الأدلة
-
How Your Body Absorbs MedicationFrom the moment you swallow a pill to the point it reaches your bloodstream, your body runs a complex absorption …
-
Liver Disease and Medication DosingThe liver metabolizes most medications. When liver function is impaired, drugs can build up to dangerous levels or fail to …
-
Medications and Liver DiseaseHow liver disease affects drug metabolism and first-pass elimination, why hepatic dose adjustments are less predictable than renal adjustments, and …
-
The Microbiome and Drug MetabolismTrillions of bacteria in your gut can transform drugs before they even reach your bloodstream. Learn how the gut microbiome …