First-Pass Effect

定義

The phenomenon where an orally administered drug is significantly metabolized by the liver before reaching systemic circulation. This reduces the amount of active drug available to the body and is a major reason why oral doses are often higher than intravenous doses of the same drug.

関連用語

ガイドでの言及

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• Liver Disease and Medication Dosing
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• Medications and Liver Disease
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• The Microbiome and Drug Metabolism
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