First-Pass Effect

정의

The phenomenon where an orally administered drug is significantly metabolized by the liver before reaching systemic circulation. This reduces the amount of active drug available to the body and is a major reason why oral doses are often higher than intravenous doses of the same drug.

관련 용어

가이드에서 언급됨

• How Your Body Absorbs Medication
  From the moment you swallow a pill to the point it reaches your bloodstream, your body runs a complex absorption …
• Liver Disease and Medication Dosing
  The liver metabolizes most medications. When liver function is impaired, drugs can build up to dangerous levels or fail to …
• Medications and Liver Disease
  How liver disease affects drug metabolism and first-pass elimination, why hepatic dose adjustments are less predictable than renal adjustments, and …
• The Microbiome and Drug Metabolism
  Trillions of bacteria in your gut can transform drugs before they even reach your bloodstream. Learn how the gut microbiome …