Clearance

정의

The volume of plasma from which a drug is completely removed per unit time, reflecting the body's efficiency at eliminating the drug. Clearance is primarily determined by liver metabolism and kidney excretion. Reduced clearance (e.g., in kidney or liver disease) means the drug accumulates, potentially causing toxicity.

관련 용어

가이드에서 언급됨

• What Is a Drug's Half-Life?
  Half-life explains how long a drug stays active in your body and determines how often you need to take it. …
• Kidney Disease and Medication Dosing
  When kidneys are not working at full capacity, many medications accumulate to dangerous levels. Learn how kidney function affects drug …
• Pediatric Dosing Principles
  Why children are not simply small adults when it comes to medications — how age and weight affect dosing, why …
• Medications and Kidney Disease
  How chronic kidney disease affects drug clearance, which drugs accumulate to dangerous levels in kidney disease, and how renal dosing …