Clearance
CLDéfinition
The volume of plasma from which a drug is completely removed per unit time, reflecting the body's efficiency at eliminating the drug. Clearance is primarily determined by liver metabolism and kidney excretion. Reduced clearance (e.g., in kidney or liver disease) means the drug accumulates, potentially causing toxicity.
Exemple
Metformin is eliminated almost entirely by renal clearance, which is why dose adjustments are required in kidney disease.
Termes Associés
Mentionné dans les Guides
-
What Is a Drug's Half-Life?Half-life explains how long a drug stays active in your body and determines how often you need to take it. …
-
Kidney Disease and Medication DosingWhen kidneys are not working at full capacity, many medications accumulate to dangerous levels. Learn how kidney function affects drug …
-
Pediatric Dosing PrinciplesWhy children are not simply small adults when it comes to medications — how age and weight affect dosing, why …
-
Medications and Kidney DiseaseHow chronic kidney disease affects drug clearance, which drugs accumulate to dangerous levels in kidney disease, and how renal dosing …