Clearance

Definition

The volume of plasma from which a drug is completely removed per unit time, reflecting the body's efficiency at eliminating the drug. Clearance is primarily determined by liver metabolism and kidney excretion. Reduced clearance (e.g., in kidney or liver disease) means the drug accumulates, potentially causing toxicity.

Verwandte Begriffe

In Leitfäden Erwähnt

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• Kidney Disease and Medication Dosing
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• Pediatric Dosing Principles
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• Medications and Kidney Disease
  How chronic kidney disease affects drug clearance, which drugs accumulate to dangerous levels in kidney disease, and how renal dosing …