Enzyme Inhibition
Definition
The process by which a drug decreases the activity of metabolizing enzymes, leading to slower breakdown and increased blood levels of co-administered drugs. Unlike induction, inhibition can occur rapidly (within hours) and may cause toxicity of the affected drug.
Beispiel
Ketoconazole inhibits CYP3A4, which can dangerously increase blood levels of certain immunosuppressants like cyclosporine.
Verwandte Begriffe
In Leitfäden Erwähnt
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The CYP450 System ExplainedAn accessible explanation of the cytochrome P450 enzyme system — the liver's main drug-processing machinery and the source of most …
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Antibiotics and Other Drug InteractionsA practical guide to the most important antibiotic-drug interactions — including effects on warfarin, oral contraceptives, antacids, and the risk …
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How Statins Lower CholesterolStatins are among the most prescribed medications in the world. They work by blocking a key enzyme in cholesterol production, …
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Complete Guide to Cholesterol MedicationsA clear explanation of the main drugs used to manage high cholesterol — statins, ezetimibe, PCSK9 inhibitors, and more — …
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Complete Guide to Acid Reflux MedicationsAn accessible guide to treating acid reflux and GERD — covering antacids, H2 blockers, proton pump inhibitors, and when each …