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Enzyme Inhibition

定義

The process by which a drug decreases the activity of metabolizing enzymes, leading to slower breakdown and increased blood levels of co-administered drugs. Unlike induction, inhibition can occur rapidly (within hours) and may cause toxicity of the affected drug.

例

Ketoconazole inhibits CYP3A4, which can dangerously increase blood levels of certain immunosuppressants like cyclosporine.

関連用語

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