Tolerance

Definition

A decrease in a drug's effect over time with repeated administration, requiring higher doses to achieve the same response. Tolerance develops through receptor downregulation, enzyme induction, or other adaptive mechanisms.

Verwandte Begriffe

In Leitfäden Erwähnt

• Medications That Cause Weight Gain
  Many commonly prescribed medications cause weight gain as a side effect. This guide explains which drug classes are most often …
• Drowsiness and Sedation from Medications
  Many medications cause drowsiness as a side effect. Learn which drug classes are most sedating, how tolerance develops, and practical …
• How Antibiotics Kill Bacteria
  Antibiotics attack bacteria through several distinct mechanisms — from punching holes in cell walls to jamming protein factories. Understanding how …
• When and How to Taper Medications
  Stopping some medications abruptly can cause serious withdrawal or rebound effects. Tapering — gradually reducing the dose — is the …
• Drug Holidays: When Taking a Break Is OK
  A drug holiday is a planned, temporary break from medication. For some drugs and conditions, this approach can reduce side …
• Complete Guide to Anxiety Medications
  A balanced overview of medications used for anxiety disorders — SSRIs, SNRIs, buspirone, benzodiazepines, and beta-blockers — including how they …
• Complete Guide to Pain Management
  A comprehensive patient guide to pain medications — from OTC analgesics to opioids — explaining different pain types, how drugs …
• Complete Guide to Sleep Medications
  A balanced guide to prescription and OTC sleep medications — benzodiazepines, Z-drugs, melatonin receptor agonists, and newer options — including …