Tolerance

Определение

A decrease in a drug's effect over time with repeated administration, requiring higher doses to achieve the same response. Tolerance develops through receptor downregulation, enzyme induction, or other adaptive mechanisms.

Пример

Patients taking opioids for chronic pain may develop tolerance, requiring dose increases over time to maintain the same level of pain relief.

Связанные Термины

Agonist Taper Drug Holiday

Упоминается в Руководствах

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