本信息仅供教育参考之用,请务必咨询医疗专业人员。 了解更多

Tolerance

定义

A decrease in a drug's effect over time with repeated administration, requiring higher doses to achieve the same response. Tolerance develops through receptor downregulation, enzyme induction, or other adaptive mechanisms.

示例

Patients taking opioids for chronic pain may develop tolerance, requiring dose increases over time to maintain the same level of pain relief.

相关术语

在指南中提及