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Antagonism (Drug Interaction)

Définition

An interaction where one drug reduces or blocks the effect of another drug. This can occur through pharmacodynamic antagonism (opposing receptor effects) or pharmacokinetic antagonism (one drug increases the metabolism of another).

Exemple

NSAIDs can antagonize the blood pressure-lowering effect of ACE inhibitors by promoting sodium retention, potentially reducing antihypertensive efficacy.

Termes Associés

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