Antagonism (Drug Interaction)
Definition
An interaction where one drug reduces or blocks the effect of another drug. This can occur through pharmacodynamic antagonism (opposing receptor effects) or pharmacokinetic antagonism (one drug increases the metabolism of another).
Example
NSAIDs can antagonize the blood pressure-lowering effect of ACE inhibitors by promoting sodium retention, potentially reducing antihypertensive efficacy.
Related Terms
Mentioned in Guides
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What Are Drug Interactions?A clear introduction to drug interactions — what they are, why they happen, and the difference between synergistic and antagonistic …
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Blood Thinner InteractionsAn in-depth guide to drug interactions with anticoagulants and antiplatelet medications — including warfarin, DOACs, and aspirin — covering both …