Synergism
Definition
An interaction where the combined effect of two drugs is greater than the sum of their individual effects. Synergism can be therapeutically beneficial (combining antibiotics) or dangerous (combining sedatives with alcohol).
Example
Trimethoprim-sulfamethoxazole (Bactrim) is a synergistic antibiotic combination — each drug inhibits a different step in bacterial folic acid synthesis, making the combination far more effective than either drug alone.
Related Terms
Mentioned in Guides
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What Are Drug Interactions?A clear introduction to drug interactions — what they are, why they happen, and the difference between synergistic and antagonistic …
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Pain Medication InteractionsA practical guide to interactions involving opioid and non-opioid pain medications — from NSAIDs and acetaminophen to opioids and adjuvant …