Serotonin Syndrome
SSDefinition
A potentially life-threatening condition caused by excessive serotonergic activity, usually from combining two or more drugs that increase serotonin levels. Symptoms include agitation, confusion, rapid heart rate, dilated pupils, muscle twitching, and hyperthermia.
Example
Combining an SSRI antidepressant with tramadol (a pain medication with serotonergic properties) can trigger serotonin syndrome.
Related Terms
Mentioned in Guides
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Major Drug Interactions Everyone Should KnowA practical guide to the most clinically significant drug-drug interactions — including serotonin syndrome and QT prolongation — that every …
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Antidepressant InteractionsA guide to the most clinically important interactions involving antidepressants — including serotonin syndrome, CYP450 effects, and interactions with pain …
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How Antidepressants WorkAntidepressants work by adjusting the balance of chemical messengers in the brain — but the story is more complex than …
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Complete Guide to Depression MedicationsA compassionate overview of antidepressant drug classes — SSRIs, SNRIs, TCAs, MAOIs, and newer options — covering how they work, …